Cover // Trends in Microbiology

In the warfare between bacteria and their viruses, the role of small molecules has been mostly overlooked. The cover image shows a schematic depiction of small antiphage molecules secreted by Streptomyces mycelium (bottom) conferring protection against phage infection at the multicellular level. In this issue, Hardy et al. summarize the current knowledge about antiphage molecules produced by bacteria and outline future directions for this rapidly expanding field.